Abstract #0275

Investigating the effect of thrombotic thrombocytopenic purpura on neurocognitive function using relaxation and myelin water fraction maps

Fahad Hannan¹, Michael T. Jurkiewicz², Jonathan Thiessen^1,2,3, and Susan Shih-Han Huang^1,4,5

¹Medical Biophysics, University of Western Ontario, London, ON, Canada, ²Medical Imaging, University of Western University, London, ON, Canada, ³Lawson Health Research Institute, London, ON, Canada, ⁴Medicine, Schulich School of Medicine & Dentistry, London, ON, Canada, ⁵The Lilibeth Caberto Kidney Clinical Research Unit, London, ON, Canada

Synopsis

Keywords: Quantitative Imaging, Neurodegeneration, Cognitive decline, neuroinflammation, myelin water fraction

Despite being in remission, patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP) experience a variety of cognitive health problems. Quantitative MRI was used to verify the health of white matter in 19 patients. Patients had increased T1 in the cingulate cortex and increased T2 in the frontal, parietal, and temporal lobes. These regions correlate with decreased cognitive scores and depression tests taken by patients alongside the MRI scan. Increased T1 and T2 could suggest a variety of tissue pathologies but require further investigation to determine exactly what condition is affecting white matter health.

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