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Abstract #0276

MRI profiling of temporal lobe epilepsy with hippocampal sclerosis using multi-compartment diffusion models

Xiaonan Zhang1, Guohua Zhao1, Huiting Zhang2, Eryuan Er Gao1, and Jingliang Cheng1
1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2MR Scientific Marketing, Siemens Healthineers Ltd., Wuhan, China

Synopsis

Keywords: Quantitative Imaging, BrainThe hippocampal microstructural alterations by using routine magnetic resonance imaging presents a challenge. This study aimed to evaluate the performance of the NODDI and MAP models in temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (HS). Our results found that all NODDI and MAP parameters had significant differences between ipsilateral HS and contralateral HS/HC, and had MAP models better diagnostic performance than NODDI. In addition, combined MAP model had significant better diagnostic performance than all the single parameters. In conclusion, MAP is superior to NODDI in diagnosing TLE with HS.

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