Keywords: Quantitative Imaging, Spectroscopy, BrainVariations in six neuro-metabolite (N-acetylaspartate, creatine, myo-inositol, glutamate, glutamine and glycerophosphorylcholine) signals from MR spectroscopy (MRS) data across eleven brain regions were tested for regional differences and for dependence on the spectroscopic volume tissue composition (fractional grey matter (GM)), using a linear mixed-effect model. We found significant positive correlations of N-acetylaspartate, creatine and glutamate concentrations with fractional GM across all eleven regions and a significant regional effect for all six metabolites. This provides clear evidence that brain metabolite measurements are dependent on both the region and fractional GM, demonstrating the importance of knowing tissue fractions when interpreting MRS measurements.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords