Abstract #0279

Effects of hypertension and type 2 diabetes on cerebrovascular reactivity in older adults

Nuwan D. Nanayakkara¹, Liesel-Ann Meusel¹, Nicole D. Anderson^1,2, and J. Jean Chen^1,3,4

¹Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, ²Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, Canada, ³Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁴Department of Biomedical Engineering, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Quantitative Imaging, Diabetes, Cerebrovascular reactivity, CVR

Differences in CVR amplitude and time delay were assessed among patients with hypertension (HT), hypertension-plus-type-2 diabetes (HT+DM), and age-matched controls (CTL) using a pipeline for adaptive capturing of the BH response directly from BOLD data, ensuring greater robustness. The lowest CVR amplitude and the longest delay were found in the HT+DM group. CTL had the highest CVR amplitude, and the HT group had the shortest time delays. CVR delay was more sensitive to group differences than amplitude.

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