Abstract #0283

Electrical Conductivity Mapping Using Ultrashort Echo Time Double Echo Steady State

Hyungseok Jang¹, Sam Sedaghat¹, Soo Hyun Shin¹, Saeed Jerban¹, Yajun Ma¹, Eric Y Chang^1,2, and Jiang Du^1,2,3

¹Department of Radiology, University of California, San Diego, San Diego, CA, United States, ²Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States, ³Department of Bioengineering, University of California, San Diego, San Diego, CA, United States

Synopsis

Keywords: Quantitative Imaging, Electromagnetic Tissue PropertiesElectrical conductivity is an intrinsic tissue property. At the Larmor frequency of the MR system (i.e., ~128 MHz at 3T), the electrical conductivity reflects the tissue composition and ionic contents. Electrical conductivity mapping (ECM) has recently emerged as a promising MR-based biomarker. In this study, we show the feasibility of ECM using ultrashort echo time double echo steady state (UTE-DESS). In addition, three ECM methods, including forward Laplacian, parabolic fitting, and inverse Laplacian, are compared in computer simulation and ex vivo experiments with four cadaveric human brain specimens.

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