Abstract #0285

The sequence of regional structural disconnectivity due to chronic active and inactive multiple sclerosis lesions

Ceren Tozlu¹, Emily Olafson¹, Keith Jamison¹, Emily Demmon², Ulrike Kaunzner², Melanie Marcille², Nicole Zinger², Nara Michaelson², Neha Safi², Thanh Nguyen¹, Susan Gauthier², and Amy Kuceyeski¹

¹Department of Radiology, Weill Cornell Medicine, NYC, NY, United States, ²Department of Neurology, Weill Cornell Medicine, NYC, NY, United States

Synopsis

In this study, we showed that structural disconnectivity due to T2 FLAIR lesions in the ventral attention and subcortical networks, in particular within the supramarginal and putamen, occurs earlier in the sequence of disability (i.e., mild to severe) in multiple sclerosis. We also showed that paramagnetic rim lesion (PRL)-based structural disconnectivity in motor-related regions occurs earlier in the disability event sequence, followed by non-PRL-based structural disconnectivity in the caudate and postcentral gyrus. T2 FLAIR lesion-based structural disconnectivity in subcortical regions, including the thalamus, occurs earliest in the sequence of cognitive impairment (i.e. preserved to impaired).

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