Abstract #0286

Metabolic Imaging of Alzheimer’s Disease Related Inflammation Using Deuterium MRI

Matthew E Merritt¹, Mario Chang¹, Tara Hawkinson¹, Anna Rushin¹, Vikram Kodibagkar², James Bankson³, and Ramon Sun¹

¹Biochemistry and Mol. Bio., University of Florida, Gainesville, FL, United States, ²School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States, ³Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States

Synopsis

Alzheimer’s Disease (AD) is characterized by increased inflammation and increased glucose utilization as detected by FDG-PET. Using a new deuterium MRI method based on a [D₇]glucose tracer, we can image the brain of a mouse model of AD with in plane resolution approaching 1 mm. Mass spectrometry imaging of the same brains shows characteristic changes in protein associated glycans that correlate well with immunohistochemical staining for inflammation. We believe this new research pipeline can provide powerful new insights into AD pathophysiology.

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