Abstract #0291

A comparison of Gadolinium- and water-based blood-brain barrier dysfunction measures in patients with small vessel disease

Michael S Stringer¹, Cameron Manning¹, Xingfeng Shao², Hedok Lee³, Antoine Vallatos⁴, Hattie Lord¹, Carmen Arteaga¹, Una Clancy¹, Daniela Jaime Garcia¹, Maria Valdes Hernandez¹, Stewart Wiseman¹, Rachel Locherty¹, Francesca Chappell¹, Rosalind Brown¹, Fergus N Doubal¹, Ian Marshall¹, Helene Benveniste^3,5, Michael J Thrippleton¹, Danny JJ Wang², and Joanna M Wardlaw¹

¹Centre for Clinical Brain Sciences and UK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom, ²Laboratory of FMRI Technology (LOFT), USC Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ³Department of Anesthesiology, Yale School of Medicine, Yale University, New Haven, CT, United States, ⁴Glasgow Experimental MRI Centre, School of Psychology and Neuroscience, University of Glasgow, Glasgow, United Kingdom, ⁵Department of Biomedical Engineering, Yale School of Medicine, Yale University, New Haven, CT, United States

Synopsis

Clinically relevant non-invasive blood-brain barrier (BBB) function imaging techniques are needed to monitor the role of neuroinflammation and endothelial cell dysfunction, particularly in small vessel disease (SVD). Diffusion-weighted ASL measures water exchange rate (k_w), a promising endogenous BBB function metric, but has not been assessed in sporadic SVD. We measured k_w in SVD patients to explore associations with established Gadolinium-based contrast agent (GBCA) BBB permeability measures and SVD severity. We found only limited associations between k_w and GBCA metrics, although patients with more severe SVD tended to have higher k_w, reflecting that the methods may probe different mechanisms.

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