Abstract #0292

Short-term changes in brain structure, perfusion and oxygen metabolism in young adults infected with Omicron: A case control study using MRI

Rui Shen¹, Jiachen Liu¹, Chenyang Zhao², Ning Xu¹, Shuwan Yu¹, Huiyu Qiao¹, Zihan Ning¹, Hualu Han¹, Zixuan Lin³, Hanzhang Lu⁴, Haiyan Ding¹, and Xihai Zhao¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, ²Department of Radiology, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China, ³College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ⁴Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baldimore, MD, United States

Synopsis

We investigated the short-term changes in brain structure, perfusion and oxygen metabolism in young adult patients infected with SARS-COV-2 Omicron but with mild symptoms in China using multimodal MRI. The clinical and brain MR imaging characteristics were compared between patient group (n=98) and healthy control group（n=50). Our findings suggest that there are no significant short-term changes in brain structure, perfusion and oxygen metabolism determined by multimodal MR imaging in young adult patients infected with SARS-CoV-2 Omicron. The potential trend of decline in the volume of cerebral nucleus in the patient group needs further investigation.

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