Abstract #0294

Tracking evolution of multiple sclerosis lesions during medication switch: a quantitative multiparametric 7T MRI approach

Myrte Strik¹, Warda T Syeda¹, Yasmin Blunck^1,2, Vivien Li^3,4,5, Rebecca Glarin¹, Scott C Kolbe⁶, Bradford A Moffat¹, Leigh A Johnston^1,2, Elaine Lui^1,7,8, and Trevor J Kilpatrick^3,4,5

¹Radiology, Melbourne Brain Centre Imaging Unit, University of Melbourne, Melbourne, Australia, ²Biomedical Engineering, University of Melbourne, Melbourne, Australia, ³Neuroimmunology and Remyelination Laboratory, Florey Institute for Neuroscience and Mental Health, Melbourne, Australia, ⁴Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia, ⁵Neurology, Royal Melbourne Hospital, Melbourne, Australia, ⁶Research Partnerships & Translation, RMIT University, Melbourne, Australia, ⁷Radiology, University of Melbourne, Melbourne, Australia, ⁸Radiology, Royal Melbourne Hospital, Melbourne, Australia

Synopsis

Multiple sclerosis patients may need to switch disease modifying treatments due to various reasons, with risk of recurrent disease activity during transition period. Identifying patients at risk is challenging. In this pilot study we used a non-conventional quantitative multi-modal 7T MRI approach to assess evolution of lesions when switching medication. We observed altered diffusion, susceptibility and T1 values three months after stopping, and these metrics returning to baseline values three months after starting new medication. Multi-modal quantitative MR techniques at ultra-high field MRI may be more sensitive to detect subtle changes over time to potentially better inform underlying disease activity.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.