Abstract #0314

Fast and High-resolution Luminal Water Imaging in the Prostate Based on Echo Merging and k-t Undersampling with Reduced Refocusing Flip Angles

Hao Li^1,2, Nikita Sushentsev², Dimitri Kessler², Shaohang Li³, Kang-Lung Lee², Andrew Nicholas Priest^2,4, Ferdia A Gallagher², and Tristan Barrett ²

¹The Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China, ²Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ³Shanghai Jiao Tong University University, Shanghai, China, ⁴Department of Radiology, CUH NHS Foundation Trust, Cambridge, United Kingdom

Synopsis

Keywords: Prostate, Cancer

The clinical application of luminal water imaging (LWI) has been restricted by its long acquisition time. We present a high acceleration method based on T₂mapping using echo merging plus k-t undersampling with reduced flip angles (TEMPURA), which enables a fast acquisition in 2.8 min as well as a high-resolution acquisition in 5.4 min. Their performance was evaluated on 13 patients with biopsy-proven prostate cancer. Compared with the standard acquisition in 8.3 min, both the fast and high-resolution methods showed a high correlation in LWI measurements and consistent diagnostic performance in detecting malignant lesions.

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