Abstract #0320

Human Prostate MRI at ultra-high-performance gradient of 200 mT/m and 500 T/m/s

Ante Zhu¹, Matthew Tarasek¹, Yihe Hua¹, Eric Fiveland¹, Desmond T.B. Yeo¹, Stephan E. Maier², Yousef Mazaheri³, Filip Szczepankiewicz⁴, Carl-Fredrik Westin², Clare Tempany², Oguz Akin³, and Thomas K.F. Foo¹

¹GE Research, Niskayuna, NY, United States, ²Brigham and Women's Hospital, Boston, MA, United States, ³Memorial Sloan Kettering Cancer Center, New York, NY, United States, ⁴Lund University, Lund, Sweden

Synopsis

Keywords: Prostate, Diffusion/other diffusion imaging techniques, Tumor, MicrostructureDiffusion MRI has been shown to yield imaging biomarkers for prostate cancer identification and grading. However, the image quality remains poor due to the limited gradient performance of clinical whole-body MRI systems. We assessed the technical feasibility of human prostate MRI in a 42-cm inner-diameter gradient coil operating at maximum gradient amplitude of 200 mT/m and slew rate of 500 T/m/s. No sensation of peripheral nerve stimulation was reported. Significantly reduced image distortion and higher image signal-to-noise ratios were achieved in diffusion MRI due to shorter echo times and shorter echo spacings, compared to diffusion MRI at whole-body MRI systems.

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