Abstract #0323
Background prostate tissue is quantitatively abnormal on T2-weighted MRI in patients with clinically significant prostate cancer
Christopher C Conlin1, Roshan Karunamuni2, Troy S Hussain2, Allison Y Zhong3, Karoline Kallis2, Deondre D Do2,4, Asona J Lui2, Garnier Mani3, Courtney Ollison5, Mariluz Rojo Domingo4, Ahmed Shabaik6, Christopher J Kane7, Aditya Bagrodia7, Rana R McKay7,8, Joshua M Kuperman1, Rebecca Rakow-Penner1, Michael E Hahn1, Anders M Dale1,9,10, and Tyler M Seibert1,2,4
1Department of Radiology, University of California San Diego, La Jolla, CA, United States, 2Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, United States, 3School of Medicine, University of California San Diego, La Jolla, CA, United States, 4Department of Bioengineering, University of California San Diego, La Jolla, CA, United States, 5Department of Biology, San Diego State University, San Diego, CA, United States, 6Department of Pathology, University of California San Diego, La Jolla, CA, United States, 7Department of Urology, University of California San Diego, La Jolla, CA, United States, 8Department of Medicine, University of California San Diego, La Jolla, CA, United States, 9Department of Neurosciences, University of California San Diego, La Jolla, CA, United States, 10Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA, United States
Synopsis
Keywords: Prostate, Cancer, T2-weighted MRI; Background prostate; Benign-appearing prostateIn this study, we examined whether patients with clinically significant prostate cancer (csPCa) have abnormal T2-weighted signal in prostate tissue outside of index lesions identified on MRI—i.e., in the background prostate (BP). In two independent patient cohorts, normalized T2-weighted signal was systematically lower in the BP of subjects with csPCa compared to those without. Reduced T2-weighted BP signal indicated the presence of csPCa with accuracy comparable to lesion-based measurements. Consideration of T2-weighted signal in the whole prostate improved patient-level detection of csPCa over DWI alone, suggesting that it provides complementary diagnostic value.
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