Abstract #0332

Free-breathing mapping of stress/rest myocardial T1 reactivity with Ferumoxytol-enhanced imaging using a widely available sequence

Hazar Benan Unal¹, Shahriar Zeynali¹, Subha Raman², Balaji Tamarappoo², Rohan Dharmakumar², and Behzad Sharif^1,2

¹Laboratory for Translational Imaging of Microcirculation, Indiana University School of Medicine, Indianapolis, IN, United States, ²Krannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, IN, United States

Synopsis

Keywords: Myocardium, Ischemia, dobutamineMyocardial T1 reactivity, defined as the relative T1 change from rest to stress, has been proposed as a marker for detection of ischemic heart disease. Commonly used MOLLI T1 mapping is sensitive to B0 field inhomogeneities and can have susceptibility/banding artifacts because of bSSFP readouts, especially at 3T. In this study, we investigated the feasibility of free-breathing SR-FLASH T1 mapping for ferumoxytol-enhanced (FE) dobutamine-stress T1 reactivity studies at 3T in preclinical settings. We showed the feasibility of using a widely available perfusion sequence for T1 reactivity studies under Ferumoxytol-enhancement.

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