Keywords: Heart, IschemiaDiffusion dispersion mapping is a recently proposed method for probing tissue microstructure and quantifying microstructural disorder based on differences in the impact of diffusion restrictions over different length scales. In this work, this method was employed in the ex vivo heart to investigate the utility of diffusion dispersion in identifying and characterizing ischemic tissue. Our results show that ischemic cardiac lesions exhibit reduced diffusion dispersion rates, in agreement with known microstructural changes, and can be differentiated with respect to surrounding tissue. These findings demonstrate that microstructure-sensitive contrast offers a novel avenue for probing and characterizing cardiac pathologies.
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