Abstract #0356

Multi-echo functional MRS Glutamate measurements in visual cortex at 3T

Polina Emeliyanova^1,2, Laura M. Parkes^1,2, Stephen R. Williams³, and Caroline Lea-Carnall^1,2

¹Division of psychology, communication and human neuroscience, Faculty of biology, medicine and health, University of Manchester, Manchester, United Kingdom, ²Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Manchester, United Kingdom, ³Division of Informatics, Imaging and Data Science, University of Manchester, Manchester, United Kingdom

Synopsis

Keywords: Data Acquisition, Spectroscopy, Functional MRS, multi-echo MRS, 3T, glutamate, creatine (Cr), N-Asetyl-Aspartate (NAA)

fMRS studies have shown dynamic change in glutamate (Glu) concentrations during visual stimulation. Here, we examine the effect of TE from 9.3-280ms on the signal during fMRS acquisition and whether T2 relaxation parameters change during a visual task compared to rest. We observed a short Glu T₂-compartment between 2.5-4.5ms arising from 48% (rest) and 16% (active) of the total signal with significant increase in Glu signal at TE =140ms during stimulation. These preliminary results indicate bi-exponential decay of Glu in the visual cortex at 3T encouraging future work with more robust fMRS paradigms.

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