Abstract #0357

In vivo Whole-brain Downfield Metabolites Mapping using 2π-CASP-EPSI at 7T

Guodong Weng^1,2, Piotr Radojewski^1,2, Federico Turco^1,2, and Johannes Slotboom^1,2

¹Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland, ²Translational Imaging Center, sitem-insel, Bern, Switzerland

Synopsis

Keywords: Pulse Sequence Design, Spectroscopy, Downfield MRSIMany interesting metabolites, for instance adenosine triphosphate (ATP), glutathione (GSH) and homocarnosine (hCs), have resonances in the downfield range (>4.7 ppm) in 1H-MRS. Previous studies have studied the downfield spectra of metabolites in human brain using single-voxel spectroscopy (SVS) and, most recently, 2D one-slice MRSI. The study presents a 3D whole brain mapping sequence suited for downfield metabolites which does not require water suppression pulses.

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