Abstract #0360

Temperature Mapping Based on Chemical Exchange Saturation Transfer of Creatine

Siqi Cai^1,2, Yang Zhou¹, Chao Zou¹, Linhai Jiang³, Qian Wan¹, Chunxiang Jiang¹, Changjun Tie¹, and Lijuan Zhang^1,2

¹Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²University of Chinese Academy of Science, Beijing, China, ³The Instrumental Analysis Center of Shenzhen University, Shenzhen University, Shenzhen, China

Synopsis

Keywords: Data Analysis, CEST & MTChemical exchange between endogenous labile guanidinium (Guan) protons of creatine and free water and its thermal dependency were investigated with CEST imaging. The apparent offsets of Cr-CEST were linearly correlated to the experiment temperatures and was relatively insensitive to Cr concentration and pH variations at a range corresponding to physiological and pathological conditions, suggesting a potential utility of Cr-CEST for in vivo thermometry based on endogeneous creatine of the biological tissue.

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