Keywords: Data Analysis, Relaxometry, Myelin, Magnetic field perturbationIn this study, the effects of myelin structures such as myelin volume fraction (MVF) and myelin sheath thickness (MST) were investigated by measuring the intra/extracellular water signals in post-mortem aging rat brains. R2 values calculated by intra/extracellular water signals obtained using Carr-Purcell-Meiboom-Gill (CPMG) sequence are theoretically verified by comparison with transmission electron microscopy (TEM) and simulation results. It was confirmed that MVF affects the increase of R2 and MST affects the decrease of R2, and the analysis of R2 through this relationship was statistically significant. These results suggest that effects of myelin structures may affect CPMG-based intra/extracellular water signals.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords