Abstract #0367
DEveloping Blood-Brain barrier arterial spin labeling as a non-Invasive Early biomarker (DEBBIE)
Beatriz Padrela1, Mervin Tee2, Markus Sneve3, Amnah Mahroo4, Oliver Geier5, David Thomas6, Catherine Morgan7, Paulien Moyaert8,9, Esin Ozturk10, Wibeke Nordhøy11, Lene Pålhaugen12, Jennifer Linn13, Per Selnes12, Klaus Eickel4,14, Simon Konstandin4,14, Joost Kuijer1, Daniel Hoinkiss4, Nora Breutigam4, Mareike Buck4, Rik Achten9, Frederik Barkhof1,15, Saima Hilal2, Tormod Fladby12,16, Udunna Anazodo8, Jan Petr17, Henk J.M.M. Mutsaerts1, and Matthias Günther4
1Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 2National University of Singapore and National University Health System, Saw Swee Hock School of Public Health, Singapore, Singapore, 3Department of Psychology, University of Oslo, Center for Lifespan Changes in Brain and Cognition, Oslo, Norway, 4Fraunhofer-Insitute for Digital Medicine MEVIS,, Bremen, Germany, 5Clinics of Radiology and Nuclear Medicine, University of Oslo, Department of Physics and Computational Radiology, Oslo, Norway, 6University College London, Dementia Research Center, London, United Kingdom, 7University of Auckland, School of Psychology and Centre for Brain Research, Auckland, New Zealand, 8Lawson Health Research Institute, London, ON, Canada, 9Department of Medical Imaging, Ghent University Hospital, Gent, Belgium, 10Bogazici University, Institute of Biomedical Engineering, Istanbul, Turkey, 11Clinics of Radiology and Nuclear Medicine, Oslo University Hospital, Department of Physics and Computational Radiology, Oslo, Norway, 12Department of Neurology, Akershus University Hospital, Lørenskog, Norway, 13Technische Universität Dresden, Department of Neuroradiology, University Hospital Carl Gustav Carus, Dresden, Germany, 14mediri GmbH, Heidelberg, Germany, 15University College London, Queen Square Institute of Neurology and Centre for Medical Image Computing (CMIC), London, United Kingdom, 16University of Oslo, Institute of Clinical Medicine, Campus Ahus, Lørenskog, Norway, 17Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany
Synopsis
Keywords: Alzheimer's Disease, AgingOne of the earliest signs of Alzheimer’s disease (AD) is the loss of blood-brain barrier (BBB) integrity. Arterial spin labeling (ASL) MRI is a non-invasive way to measure perfusion and several other hemodynamic and physiological parameters, including vascular permeability. The DEveloping BBB-ASL as non-Invasive Early biomarker (DEBBIE) consortium aims to develop and integrate innovative techniques to allow robust BBB permeability assessments by ASL to develop a sensitive, non-invasive, and early biomarker for AD and related dementias. This work summarizes our planned efforts to develop and establish an MRI-based BBB permeability biomarker.
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