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Abstract #0373

Balanced Steady-State Free Precession and Radial Sampling for Arterial Spin Labeled Perfusion Imaging

Paul Han1,2, Thibault Marin1,2, Yue Zhuo1,2, Jinsong Ouyang1,2, Georges El Fakhri1,2, and Chao Ma1,2
1Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Arterial spin labelling, Perfusion, BrainArterial spin labeling (ASL) is a non-invasive MRI technique that allows to quantitatively measure cerebral blood flow. However, the major limitation of ASL is in the intrinsically low signal-to-noise ratio (SNR). Balanced steady-state free precession (bSSFP) sequence has been proposed to mitigate this limitation, however, bSSFP is sensitive to off-resonance effects. ASL perfusion imaging with bSSFP can be sensitive to effects from motion and flow when Cartesian sampling scheme is used. This work proposes and investigates radial sampling scheme for ASL with bSSFP to allow perfusion imaging with relatively high SNR and robustness to motion and off-resonance effects.

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Keywords