Abstract #0374

Simultaneous 4D ASL angiography and perfusion MRI using time-encoded pCASL preparation with Stack of Spirals readout

Merlijn C.E. van der Plas^1,2, Kirsten Koolstra³, Martijn Nagtegaal², Emiel Hartsema², Lena Vaclavu², Sophie Schmid², Leoni Petitclerc², Peter Bornert⁴, and Matthias van Osch²

¹University Medical Center Utrecht, Utrecht, Netherlands, ²C.J. Gorter Center for high field MRI, Leiden University Medical Center, Leiden, Netherlands, ³Phillips, Best, Netherlands, ⁴Phillips, Hamburg, Germany

Synopsis

Keywords: Arterial spin labelling, PerfusionIn this study, a framework was set up for the simultaneous acquisition of 4D MRA and perfusion ASL data while maintaining whole brain coverage. A Hadamard-8 preparation was combined with a 3D Stack of Spirals readout which resulted in 7 timepoints. By combining these two techniques we were able to obtain both angiography and perfusion from a single dataset. By improving the efficiency of the sampling scheme i.e. using variable density spirals, the total scan time could be reduced further while improving the SNR during the perfusion phase, albeit at the expense of the quality of the 4D MRA.

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