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Abstract #0376

Analytical model for determination of exchange times in multi-TE velocity-selective Arterial Spin Labeling

Mareike Alicja Buck1,2, Klaus Eickel1,3, and Matthias Günther1,2,3
1Fraunhofer MEVIS, Bremen, Germany, 2University Bremen, Bremen, Germany, 3mediri GmbH, Heidelberg, Germany

Synopsis

Keywords: Arterial spin labelling, Arterial spin labelling, velocity-selective Arterial Spin Labeling, multi-TEIn this work, for the first time, an analytical model for determining the exchange times for obtaining vascular permeability information in velocity-selective Arterial Spin Labeling (VSASL) with multiple echo times (TE) is presented. Signal intensity comparisons were performed between different multi-TE VSASL techniques with each of the standard multi-TE pCASL and multi-TE PASL techniques for different sampling times. This demonstrates that, particularly for longer arterial transit times, the VSASL signal is twice as high compared with standard multi-TE measurements and thus shows promise in the field of non-invasive permeability measurements.

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Keywords