Abstract #0377

Oxygen Extraction Fraction mapping between normal cognition and mild cognitive impairment in an elderly cohort using quantitative BOLD

Linh N. N. Le¹, Gregory J. Wheeler¹, Evan Fletcher², Nicholas P. Blockley³, and Audrey P. Fan^1,2

¹Department of Biomedical Engineering, University of California, Davis, Davis, CA, United States, ²Department of Neurology, University of California, Davis, Davis, CA, United States, ³School of Medicine & Health Sciences, University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Oxygenation, AgingOxygen Extraction Fraction (OEF) is a valuable indicator of brain physiology influenced by cognitive impairment and vascular pathology in older adults. Our objective is to explore age-related OEF change for cognitively normal (CN) and Mild-Cognitive-Impairment (MCI) subjects. In this study, 56 elderly participants were recruited. Individuals with MCI resulted in higher OEF compared to CN participants, especially in the occipital lobe (p=0.007). In parietal lobe, we observed an inverse correlation between OEF and age (p=0.026) in CN and positive association between OEF and executive function (p=0.023) in MCI. The results showed an effect of aging and cognitive impairment on OEF

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.