Abstract #0378

Investigating the applicability of dual echo ASL for simultaneous BOLD- and CBF-based mapping of cerebrovascular reactivity

Gabriel Hoffmann^1,2, Franziska Richter¹, Jan Kufer¹, Lena Schmitzer¹, Carina Gleißner¹, Jens Göttler¹, Stephan Kaczmarz^1,2,3, and Christine Preibisch^1,2

¹Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, ²TUM-Neuroimaging Center, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, ³Philips GmbH Market DACH, Hamburg, Germany

Synopsis

Keywords: Multi-Contrast, Validation, Cerebrovascular reactivity

Combined measurement of BOLD- and CBF-based CVR by means of deASL would be valuable for assessment of cerebrovascular diseases. To investigate the applicability of deASL for CVR mapping, we acquired GE-EPI, deASL and pCASL data from 21 healthy volunteers during a hypercapnia challenge. BOLD-CVR from deASL was slightly but significantly less sensitive to hypercapnia-induced BOLD signal changes than GE-EPI, while differences between deASL- and pCASL-based CBF-CVR were rather insignificant. However, deASL failed in 5 of 21 subjects, while pCASL and GE-EPI merely failed in two and one subjects, respectively. Thus, we expect an elevated deASL failure rate in patient populations.

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