Abstract #0379

Quantitative perfusion mapping by BOLD-DSC MRI with transient hypoxia in mouse under volatile anesthetics

THI THUY LE^1,2,3, GEUN HO IM¹, CHAN HEE LEE¹, and SEONG-GI KIM^1,2,3

¹Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, 16419, Republic of Korea, Suwon, Korea, Republic of, ²Department of Biomedical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea, Suwon, Korea, Republic of, ³Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, 16419, Republic of Korea, Suwon, Korea, Republic of

Synopsis

Keywords: Hematologic, DSC & DCE Perfusion

Transient hypoxia-induced BOLD-DSC perfusion imaging approach can noninvasively map cerebral blood flow (CBF) and cerebral blood volume (CBV) in animals with injectable anesthetics. Since animal models are frequently investigated in translational research under volatile anesthetics, we developed a simple gas delivery system for inducing transient hypoxia, and performed perfusion studies of mouse under isoflurane and dexmedetomidine. Highly sensitive and reproducible perfusion metrics were found, and regional impact of anesthesia to basal perfusion metrics was assessed.

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