Meeting Banner
Abstract #0380

Population Brain Perfusion Imaging: Arterial Spin Labeling in UK Biobank

Thomas W Okell1, Karla L Miller1, Martin Craig2, Fidel Alfaro-Almagro1, David L Thomas3,4, Enrico De Vita5, Matthias Günther6, Paul M Matthews7, Stephen M Smith1, and Michael A Chapell2
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 3Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 4Dept of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 5MR Physics group, Radiology Department, Great Ormond Street Hospital, London, United Kingdom, 6Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany, 7Department of Brain Sciences, Imperial College London, London, United Kingdom

Synopsis

Keywords: Arterial spin labelling, Arterial spin labellingUK Biobank is an ongoing study which will acquire brain imaging in 100,000 participants, along with detailed lifestyle, biochemical and genetic information, and long-term health records. Here we describe the recent addition of arterial spin labeling (ASL) perfusion imaging to UK Biobank, with preliminary analyses of the first ~3,500 subjects. These revealed a range of highly significant associations between ASL metrics and non-imaging measures (e.g., blood pressure), as well as other imaging measures (e.g., white matter hyperintensity volume). This should become a useful resource for studying perfusion differences across a population and prior to disease onset.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords