Abstract #0407

Coupling between low-frequency hemodynamic oscillations and cerebrospinal fluid flow is altered in patients with cerebral amyloid angiopathy

Lydiane Hirschler^1,2, Maria Clara Zanon Zotin¹, Laura D Lewis^3,4, Mitchell J Horn¹, M. Edip Gurol¹, Anand Viswanathan¹, Jonathan R. Polimeni⁴, Matthias JP van Osch², Susanne J van Veluw^1,2, and Steven M Greenberg¹

¹Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ²C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Biomedical Engineering, Boston University, Boston, MA, United States, ⁴Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States

Synopsis

Keywords: Dementia, Neurofluids, Neurovascular, small vessel diseaseCerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid-β in the vessel walls. Prominent manifestations of CAA include enlarged perivascular spaces (ePVS) and lower amyloid-β concentrations in CSF, which may be the result of impaired brain clearance. CAA patients also demonstrate impaired evoked vascular reactivity. Whether vascular dysfunction is associated with impaired fluid movement in the human brain remains unclear. Here we show that BOLD-CSF coupling is reduced in CAA patients compared to elderly controls, which is a first demonstration of a cerebral small vessel disease affecting CSF motion.

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