Abstract #0408

Cerebrovascular reactivity (CVR) MRI as a biomarker for small vessel disease related cognitive decline: validation in the MarkVCID Consortium

Peiying Liu^1,2, Zixuan Lin¹, Kaisha Hazel¹, George Pottanat¹, Cuimei Xu¹, Dengrong Jiang¹, Emma Lucke¹, Christopher E. Bauer³, Brian T. Gold³, Steven M. Greenberg⁴, Karl G. Helmer⁵, Kay Jann⁶, Gregory A. Jicha³, Joel Kramer⁷, Pauline Maillard⁸, Rachel Mulavelil⁹, Pavel Rodriguez⁹, Claudia L. Satizabal⁹, Sudha Seshadri⁹, Herpreet Singh⁵, Angel G. Velarde⁹, Danny J.J. Wang⁶, Rita R. Kalyani¹, Abhay Moghekar ¹, Paul B. Rosenberg¹, Sevil Yasar¹, Marilyn Albert¹, and Hanzhang Lu¹

¹Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²University of Maryland School of Medicine, Baltimore, MD, United States, ³University of Kentucky, Lexington, KY, United States, ⁴Harvard Medical School, Boston, MA, United States, ⁵Massachusetts General Hospital, Boston, MA, United States, ⁶University of Southern California, Los Angeles, CA, United States, ⁷University of California, San Francisco, San Francisco, CA, United States, ⁸University of California, Davis, Sacramento, CA, United States, ⁹UT Health San Antonio, San Antonio, TX, United States

Synopsis

Keywords: Dementia, Blood vesselsSmall vessel disease (SVD) related vascular contributions to cognitive impairment and dementia (VCID) represent a major factor in cognitive decline in older adults. However, there has not been a validated biomarker for the diagnosis and treatment monitoring of this condition. Recently, the US National Institute on Neurological Disorders and Stroke (NINDS), a branch of NIH, funded a MarkVCID consortium, the goal of which is to identify and validate clinical-trial-ready biomarkers for VCID. Cerebrovascular reactivity (CVR) MRI was one of the selected biomarkers that underwent multi-site testing. The present work reports the relationship between CVR and cognitive function, and examines whether the pre-specified hypothesis can be reproduced at each of the sites.

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