Abstract #0409

Thalamic nuclei changes in early vs. late onset Alzheimer’s Disease

Gonzalo Forno^1,2, Michael Hornberger³, Albert Lladó¹, and Manojkumar Saranathan⁴

¹Alzheimer’s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic of Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain, ²Escuela de Psicología, Universidad de los Andes, Santiago, Chile, ³University of East Anglia, Norwich, United Kingdom, ⁴Radiology, University of Massachusetts Chan Medical School, Worcester, MA, United States

Synopsis

Keywords: Alzheimer's Disease, SegmentationAge at symptom onset distinctly affects thalamic nuclei alongside AD. While Early Onset AD showed significant anteroventral (AV) nucleus changes associated with increasing tau pathology, Late onset AD AV nucleus was associated with Aβ42 levels but no significant volume changes were found.

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