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Abstract #0410

Alzheimer's disease neuropathology contributes to perivascular and parenchymal free water diffusion characteristics

Kirsten Mary Lynch1, Arthur W Toga1, and Jeiran Choupan1,2
1USC Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Los Angeles, CA, United States, 2Research, NeuroScope Inc., Scarsdale, NY, United States

Synopsis

Keywords: Alzheimer's Disease, NeurofluidsDisruption of perivascular and interstitial fluid transport in the brain may contribute to the accumulation of toxic metabolic deposits observed in neurodegeneration. However, the relationship between AD neuropathology and free water fluid dynamics are not well understood. Using multi-compartment diffusion models, we assessed the relationship between PET tau and Aβ uptake and free water diffusion properties. We found tau deposition was associated with reduced free water anisotropy in brain regions that undergo neurodegeneration in pre-clinical AD. These findings provide a preliminary link between AD pathology and fluid transfer that may indicate waste clearance functional alterations.

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