Keywords: Alzheimer's Disease, NeurofluidsDisruption of perivascular and interstitial fluid transport in the brain may contribute to the accumulation of toxic metabolic deposits observed in neurodegeneration. However, the relationship between AD neuropathology and free water fluid dynamics are not well understood. Using multi-compartment diffusion models, we assessed the relationship between PET tau and Aβ uptake and free water diffusion properties. We found tau deposition was associated with reduced free water anisotropy in brain regions that undergo neurodegeneration in pre-clinical AD. These findings provide a preliminary link between AD pathology and fluid transfer that may indicate waste clearance functional alterations.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords