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Abstract #0417

White Matter Neurometabolite Vulnerability Predicts Cognitive Decline in Alzheimer’s Disease: A High-Resolution 3D 1H-MRSI Study

Danni Wang1, Miao Zhang2, Yibo Zhao3,4, Yudu Li3,5, Wen Jin3,4, Jialin Hu1, Yaoyu Zhang1, Biao Li2, Jun Liu6, Binyin Li6, Zhi-Pei Liang3,4, and Yao Li1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University of Medicine, Shanghai, China, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 6Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University of Medicine, Shanghai, China

Synopsis

Keywords: Alzheimer's Disease, SpectroscopyWhite matter (WM) damage plays an important role in AD and different mechanisms have been suggested for different brain areas from postmortem studies. Understanding the spatial patterns of pathological changes in WM is of great importance in AD diagnosis. Using a high-resolution 3D MRSI technique, we investigated the spatial patterns of neurometabolic changes in WM regions. We firstly derived neurometabolite vulnerability maps in AD, showing spatially varying patterns of NAA reduction and mIn elevation in WM regions, in distinct association with gray matter volume or Aβ deposition, respectively. The neurometabolic biomarkers showed improved prediction of cognitive decline of AD patients.

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