Abstract #0433

MRF-derived T1 and T2 map alterations in four different brain atrophy patterns in a cohort of MCI subjects

Paolo Bosco¹, Laura Biagi¹, Matteo Cencini¹, Marta Lancione¹, Michela Matteoli², Simona Cintoli³, Alessandro Sale², Nicoletta Berardi², Michela Tosetti¹, and the Train the Brain Consortium⁴

¹IRCCS Stella Maris Foundation, Pisa, Italy, ²Institute of Neuroscience of the CNR, Pisa, Italy, ³Azienda Ospedaliero Universitaria Pisana, Pisa, Italy, ⁴the Train the Brain Consortium, Pisa, Italy

Synopsis

Keywords: MR Fingerprinting/Synthetic MR, Alzheimer's DiseaseBrain atrophy evaluation is crucial in the assessment of neurodegenerative diseases. However, the most common MRI measures (mostly T1-weighted derived) cannot be considered as quantitative. In this study we use T1-weighted images to identify homogeneous groups of MCI subjects in terms of brain atrophy and we assessed the capability of T1 and T2 quantification through MRF technique to elucidate at voxel level the brain alterations with respect to an age-matched healthy population. Indeed, atrophy patterns can be identified in both T1 and T2 maps paving the way to innovative brain atrophy assessment in a quantitative fashion.

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