Abstract #0448

Inspecting placental microstructure in pregnancies affected by fetal congenital heart disease

Daniel Cromb^1,2, Paddy J Slator³, Anthony Price^1,2, Megan Hall^1,2, Daniel Alexander³, Joseph V Hajnal^1,2, Mary Rutherford^1,4, Jana Hutter^1,2, and Serena J Counsell^1,2

¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ³Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ⁴MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom

Synopsis

Keywords: Placenta, Placenta, Diffusion, MicrostructureCongenital heart disease (CHD) is common and associated with abnormal placental development. We used novel diffusion MRI acquisition and analysis techniques to inspect placental microstructure in pregnancies affected by congenital heart disease (CHD), highlighting the potential value of this approach for in-utero identification of how placental development may deviate from normal in CHD.

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