Abstract #0450

Cotyledon-Specific Flow Evaluation of Rhesus Macaque Placental Injury using Ferumoxytol Dynamic Contrast Enhanced MRI

Ruiming Chen¹, Daniel Seiter¹, Logan T. Keding^2,3, Jessica Vazquez^2,3, Kathleen Antony⁴, Heather A. Simmons^2,3, Kevin M. Johnson^1,5,6, Aleksandar K. Stanic⁴, Ruo-Yu Liu¹, Dinesh Shah⁴, Thaddus G. Golos^2,3, and Oliver Wieben^1,5,6

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, United States, ³Comparative Biosciences, University of Wisconsin - Madison, Madison, WI, United States, ⁴Obstetrics & Gynecology, University of Wisconsin - Madison, Madison, WI, United States, ⁵Radiology, University of Wisconsin - Madison, Madison, WI, United States, ⁶Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States

Synopsis

Keywords: Placenta, DSC & DCE PerfusionPlacental blood flow is a marker that reflects the health of the utero-placental vasculature. Dynamic contrast-enhanced (DCE) MRI is more robust than arterial spin labeling and can be utilized in animal models to provide cotyledon-specific blood flow and blood volume measurements in vivo throughout gestation. This study investigated the distribution of blood flow to the placental at a cotyledon level in pregnant rhesus monkeys before and following the injection of Tisseel (a fibrin sealant) and MCP1 (an inflammatory response inducer) to assess the predictabilities of flow for placental injury.

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