Abstract #0451

Affinity of Structural White Matter Tracts between Infant and Adult Pigs

Wenwu Sun¹, Ishfaque Ahmed¹, Stephanie Dubrof², Franklin West³, Hea Jin Park², and Qun Zhao¹

¹Department of Physics and Astronomy, Franklin College of Arts and Sciences, University of Georgia, Athens, GA, United States, ²College of Family and Consumer Sciences, University of Georgia, Athens, GA, United States, ³Regenerative Bioscience Center, University of Georgia, Athens, GA, United States

Synopsis

Keywords: Brain Connectivity, Diffusion/other diffusion imaging techniques, TractographyAffinity of structural white matter tracts during development is critical for longitudinal studies of many neurological diseases and brain injuries. Diffusion weighted imaging (DWI) data was collected from 3-week-old piglets. Data-driven tractography analysis was applied to profile white matter tracts for the piglets, which were then compared to recently reported 27 adult pig white matter tracts. Among the 27 tracts, 17 were found with consistent high spatial correlations between infant and adult pigs. This result provides possibilities to further study white matter during development, and to evaluate how different interventions (e.g., TBI) alter the brain myelination trajectory.

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