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Abstract #0452

Radiomic profiling and classification of active vs. inactive multiple sclerosis lesions using quantitative MRI

Tamar Blumenfeld-Katzir1, Stephanie Khoury1, Shir Didi1, Neta Stern1, Chen Hoffmann2,3, Dvir Radunsky1, Shai Shrot2,3, Dominique Raichman2,3, and Noam Ben-Eliezer1,4,5
1The Department of Biomedical Engineering, Tel-Aviv University, Tel-Aviv, Israel, 2Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 3Department of Diagnostic Imaging, Sheba Medical Center, Ramat-Gan, Israel, 4Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel, 5Center for Advanced Imaging Innovation and Research (CAI2R), New-York University Langone Medical Center, New-York, NY, United States

Synopsis

Keywords: Multiple Sclerosis, Contrast AgentMultiple sclerotic (MS) patients undergo routine MRI examination in order to monitor disease state and progression. The gold standard way to assess disease activity is by identifying the amount of active lesions using contrast enhanced imaging. The use of gadolinium-based contrast agents constitute a major radiologic concern as these are known to accumulate in the body for years without an effective clearance mechanism. In this study we investigated the utility of Radiomic profiling of lesions as an alternative for contrast injection. We show that the quantitative MRI (qMRI) markers have the potential to classify lesions to active/inactive.

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