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Abstract #0453

Repetitive Mild Traumatic Brain Injury Induces Significant Changes on Functional Connectivity with Different Impact Numbers in Rats

Yi-Han Kao1, Chia-Feng Lu1, Bao-Yu Hsieh2,3, and Yu-Chieh Jill Kao1
1Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming Chiao-Tung University, Taipei, Taiwan, 2Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, 3Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan

Synopsis

Keywords: Traumatic brain injury, Animals, rsfMRI

In the current study, we discussed about changes of brain connectivity through rsfMRI and behavioral performances following repetitive mild traumatic brain injury (rmTBI) with different impact numbers and intervals. In rats with larger impact number but longer inter-injury interval, may show anxiety-like behavior with the significant reduction of connectivity in their DMN.

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Keywords