Abstract #0453

Repetitive Mild Traumatic Brain Injury Induces Significant Changes on Functional Connectivity with Different Impact Numbers in Rats

Yi-Han Kao¹, Chia-Feng Lu¹, Bao-Yu Hsieh^2,3, and Yu-Chieh Jill Kao¹

¹Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming Chiao-Tung University, Taipei, Taiwan, ²Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, ³Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan

Synopsis

Keywords: Traumatic brain injury, Animals, rsfMRI

In the current study, we discussed about changes of brain connectivity through rsfMRI and behavioral performances following repetitive mild traumatic brain injury (rmTBI) with different impact numbers and intervals. In rats with larger impact number but longer inter-injury interval, may show anxiety-like behavior with the significant reduction of connectivity in their DMN.

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