Abstract #0455
Exploring whether differences in brain diffusion MRI metrics distinguish symptom phenotypes in athletes exposed to repetitive head impacts.
Joshua P McGeown1,2, Maryam Tayebi1,3, Matthew A McDonald1,4, Paul Condron1, Samantha Holdsworth1,5, Leigh Potter1,6, Davidson Taylor1,7, Patrick McHugh1,8, Miao Qiao9, Jerome Maller10, Justin Fernandez3, Vickie Shim1,3, Mangor Pedersen11, and Eryn E Kwon1,3,5
1Mātai Medical Research Institute, Tairāwhiti-Gisborne, New Zealand, 2Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, 3Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand, 4Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, 5Faculty of Medical and Health Sciences & Centre for Brain Research, University of Auckland, Auckland, New Zealand, 6Ngāti Porou, Ngāti Kahungunu, Rongomaiwahine, Rongowhakaata, Tairāwhiti-Gisborne, New Zealand, 7Ngai Tāmanuhiri, Rongowhakaata, Ngāti Porou, Tairāwhiti, New Zealand, 8Turanga Health, Tairāwhiti-Gisborne, New Zealand, 9School of Computer Science, Faculty of Science, University of Auckland, Auckland, New Zealand, 10General Electric Healthcare, Victoria, Australia, 11Department of Psychology and Neuroscience, Auckland University of Technology, Auckland, New Zealand
Synopsis
Keywords: Traumatic brain injury, Diffusion Tensor Imaging, SymptomologyIt is important to account for the heterogeneity of clinical presentation when studying mild traumatic brain injury (mTBI) with advanced brain imaging. We used post-season symptom data from a cohort of rugby players exposed to repetitive head impacts, and we applied unsupervised learning to cluster athletes into clinically distinct groups. We explored whether these clusters demonstrated post-season group differences in white matter tracts compared to controls. This analysis framework suggests that group differences of diffusion metrics in athletes exposed to repetitive head impacts may be associated with clinical presentation rather than generalisable across all participants.
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