Abstract #0456
Association between brain metabolites and head impact exposure measured with MRS in a cohort of high school American football athletes
Zexuan Liu1, Jonathan A. Dudley2, Nadine Ahmed3, Jed A. Diekfuss4,5,6, David A. Edmondson2,7, Kim M. Cecil2,7, Weihong Yuan2,7, Taylor M. Zuleger4,5,6,8, Alexis B. Slutsky-Ganesh4,5,6,9, Kim D. Barber Foss4,5,6, Gregory D. Myer4,5,6,10, and Candace C. Fleischer1,11
1Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States, 2Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 3Department of Neuroscience, Georgia Institute of Technology, Atlanta, GA, United States, 4Emory Sports Performance And Research Center (SPARC), Flowery Branch, GA, United States, 5Emory Sports Medicine Center, Atlanta, GA, United States, 6Department of Orthopedics, Emory University School of Medicine, Atlanta, GA, United States, 7Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States, 8Neuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, United States, 9Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, NC, United States, 10The Micheli Center for Sports Injury Prevention, Waltham, MA, United States, 11Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States
Synopsis
Keywords: Traumatic brain injury, SpectroscopyDiagnosis and prognosis of sports-related concussion is challenging. In this prospective controlled clinical trial of 215 high school American football athletes, we evaluated relationships between brain metabolite and head impacts as a function of concussion diagnosis and wearing a jugular vein compression (JVC) collar. Changes in total choline between pre- and post-season, measured with MR spectroscopy, were positively correlated with mean g-force thresholds above 80g in athletes diagnosed with a concussion, suggesting choline may be a key metric of injury. Metabolite alterations were minimally affected by the JVC collar and only at mean g-force thresholds of 100, 110 and 120g.
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