Abstract #0462

Quantitative Susceptibility Mapping in Patients with Persistent-Post Concussion Symptoms

Tiffany K Bell^1,2,3, Muhammad Ansari⁴, Leah Mercier^2,5, David G Gobbi⁶, Richard Frayne^1,2,5,6, Chantel Debert^2,5, and Ashley D Harris^1,2,3

¹Department of Radiology, University of Calgary, Calgary, AB, Canada, ²Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ³Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ⁴Department of Biomedical Engineering, University of Calgary, Calgary, AB, Canada, ⁵Department of Clinical Neuroscience, University of Calgary, Calgary, AB, Canada, ⁶Calgary Image Processing and Analysis Centre, University of Calgary, Calgary, AB, Canada

Synopsis

Keywords: Traumatic brain injury, Quantitative Susceptibility mapping, "Persistent Post-Concussion Symptoms"Twenty percent of people experience symptoms months to years following a concussion, known as persistent post concussive symptoms (PPCS). We used quantitative susceptibility mapping (QSM) to measure tissue susceptibility in white matter tracts of patients with PPCS. We provide preliminary evidence for alterations in white matter susceptibility in patients with PPCS and show that susceptibility levels are correlated with symptom severity. We hypothesise altered susceptibility is related to gliosis, resulting in sustained inflammation. Further, this study demonstrates the potential application of QSM to provide novel information on the pathophysiology of PPCS.

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