Abstract #0471

Cardiac CEST MRI under the influence of very short saturation pulses – an analysis approach

Daniel Schache¹, Ajay Peddi¹, Ali Nahardani², Cornelius Faber¹, and Verena Hoerr^1,2

¹Translational Research Imaging Center, Clinic of Radiology, University of Münster, Münster, Germany, ²Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany

Synopsis

Keywords: Data Analysis, CEST & MT

Cardiac CEST MRI in mice rely on the application of very short saturation pulses. These pulses cause disturbing signal modulation in the CEST spectrum preventing a consistent data analysis. To correct for this, an additional approach named DOSE was established in the data analysis pipeline. The DOSE-corrected analysis was validated in vitro on a glucose concentration series as well as in vivo on cardiac glucoCEST experiments of nine healthy mice. Hereby, oscillations in the CEST spectra could be reduced substantially ensuring a consistent quantification.

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