Abstract #0477

Targeted Gastric Electrical Stimulation Modulates Functional Connectivity of the Interoceptive Network in the Rat Brain

Fatimah M. Alkaabi^1,2, Jiayue Cao¹, Angela Yee¹, Xiaokai Wang¹, Ulrich Scheven¹, Chih Hsuan Tsai¹, Ana C. Saavedra¹, and Zhongming Liu^1,3

¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, ²Biomedical Engineering, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, ³Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, United States

Synopsis

Keywords: Data Analysis, AnimalsGastric Electrical Stimulation (GES) is an FDA approved therapy for gastroparesis with unspecified working mechanisms. One plausible mechanism is that it activates the vagal afferents to engage the brain’s interoceptive network in regulating the stomach. Orientation and location-specific stimulation that targets the vagal-gastric receptors can effectively activate the brainstem. We asked whether and how this type of GES can engage interoceptive regions and modulate their interactions, especially the anterior cingulate (ACC) and insular cortices (IC), the primary visceromotor and viscerosensory processing regions, respectively. Therefore, we evaluated the functional connectivity in the rat brain before, during, and after targeted GES.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.