Abstract #0478

Reproducibility of conventional and GABA-edited multi slice MRSI in the human brain at 3T

Dillip K. Senapati^1,2, Helge J. Zöllner^1,2, Ipek Özdemir ^1,2, Georg Oeltzschner^1,2, Doris D.M. Lin^1,2, and Peter B. Barker^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Keywords: Data Analysis, Spectroscopy, GABA, MR Spectroscopy, MRSI, Reproducibility, BrainReproducibility of both conventional and GABA-edited multi-slice MRSI of the human brain recorded at 3T was investigated in 11 healthy adult volunteers. GABA-edited data were post-processed using a retrospective motion compensation (MoCo) scheme. Test-retest coefficients of variation(CV) were calculated. Overall reproducibility was good for conventional MRSI for selected brain regions, but edited-MRSI data showed significant variations. Edited-MRSI scans may benefit from both improved post-doc correction schemes to minimize subtraction artifacts, as well as better B₀field homogeneity over the brain, and possibly also prospective MoCo schemes.

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