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Abstract #0482

Multiscale Entropy Analysis of Resting State fMRI in Pre-Adolescents with ADHD

Ru Zhang1, Kay Jann1, Danny J.J. Wang1, Christina J. Duval2, and Stuart B. Murray2
1Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, 2Department of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: Data Analysis, fMRI (resting state)The current study used resting state functional magnetic resonance imaging to measure the complexity of pre-adolescents with ADHD but no other comorbidities. We ran a factorial 2 (Group: ADHD, Control) by 2 (Sex: Male, Female) analyses of covariance on the multiscale entropy (MSE) maps with the pubertal development status as a covariate. It revealed MSE values were significantly lower in the ADHD group than the control group in various regions, including bilateral superior frontal gyrus, bilateral precuneus, right inferior/middle frontal gyrus/postcentral gyrus/insular, and left precentral gyrus/middle cingulate gyrus (t = -3.131 to -2.445, p < 0.015).

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Keywords