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Abstract #0485

Age-related differences in dynamic cerebrovascular reactivity based on CO2-response modelling

Colette Clare Milbourn1, Seyedmohammad J Shams2, and Jean J Chen2,3,4,5
1School of Life Sciences, University of Nottingham, Nottingham, United Kingdom, 2Research, Rotman Research Institute, Toronto, ON, Canada, 3Research, Baycrest Health Sciences Centre, Toronto, ON, Canada, 4Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 5Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Data Analysis, Neuroscience, blood vessels, cerebrovascular reactivity, deconvolution Secondary category: contrast mechanismCerebrovascular Reactivity (CVR) was measured in healthy, young and older adults. Specifically, dynamic CVR (dCVR) was measured as the carbon dioxide (CO2)-response function. This was estimated by deconvolving a sinusoidal hypercapnic time course from simultaneously acquired blood oxygen level dependent (BOLD) fMRI data using a canonical-correlation (CCA) based approach. The results demonstrate differences in dCVR amplitude and rise time between age groups. This proof-of-concept study establishes the feasibility of dCVR modelling for the study of aging.

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