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Abstract #0489

Combined fMRS and fMRI During Reinforcement Learning in a Large Cohort at 7T: When Does Cognitive Processing Occur?

Tal Finkelman1, Edna Furman-Haran2, Kristoffer Carl Mikael Aberg3, Rony Paz3, and Assaf Tal1
1Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 2life sciences core facilities, Weizmann Institute of Science, Rehovot, Israel, 3Brain Sciences, Weizmann Institute of Science, Rehovot, Israel

Synopsis

Keywords: Spectroscopy, fMRI (task based), functional MRSWe present multimodal functional MRS-fMRI-Behavioral data, which demonstrates how the E/I balance changes in the dACC during a reinforcement learning paradigm. The E/I balance decreases during rest periods between tasks, supporting a consolidation phase that is invisible to BOLD-fMRI. Additionally, we find a significant negative correlation between both GABA and glutamate, and the mean z-score of the BOLD signal from the spectroscopic voxel, during the decision-making game. We suggests that the elevation in Glu is related to cellular activity rather than neuronal activity, indicating a GABAergic activation during the task.

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