Abstract #0491

sLASER Performed Similarly to PRESS at Revealing Metabolite-Age Correlations

Steve C.N. Hui^1,2, Tao Gong^3,4, Helge J. Zöllner^1,2, Kathleen Hupfeld^1,2, Aaron Gudmundson^1,2, Yulu Song^1,2, Saipavitra Murali-Manohar^1,2, Christopher Davies-Jenkins^1,2, Georg Oeltzschner^1,2, Guangbin Wang^3,4, and Richard A. E. Edden^1,2

¹Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ⁴Department of Radiology, Shandong University, Jinan, China

Synopsis

Keywords: Spectroscopy, Data Analysis, magnetic resonance spectroscopy, sLASER, PRESS, localization, agingRecent MRS community consensus recommended sLASER over PRESS for reduced chemical-shift displacement. There is very little evidence supporting this consensus in terms of ability to reveal in vivo biochemistry. sLASER- and PRESS-localized spectra were collected in gray- and white-matter regions in 102 adult subjects (aged 20-69). sLASER showed slightly higher SNR than PRESS (by 4% on average), but improved SNR and localization did not convert into reduced variance or improved detection of metabolite-age correlations. Between-subject CVs of 13 modeled metabolites were remarkably consistent, and the pattern of metabolite-age correlations was also similar.

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