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Abstract #0493

Use of fast B1 shimming to enable localized MR spectroscopy in different regions of the human brain on a clinical platform at 7 Tesla

Özlem Ipek1,2, Jeremie Clement1,3, Marzena Arridge4, Philippa Bridgen2, Tom Wilkinson2, Laura Mancini4, Raphael Tomi-Tricot2,5, Enrico de Vita2,6, and Ralf Mekle7
1Biomedical Engineering, King's College London, London, United Kingdom, 2London Collaborative Ultra high field System (LoCUS), King's College London, London, United Kingdom, 3System Technologies, Siemens Healthcare GmbH, Erlangen, Germany, 4Lysholm Department of Neuroradilogy, National Hospital for Neuroradiology and Neurosurgery, London, United Kingdom, 5MR Research Collaborations, Siemens Healthiness, Frimley, United Kingdom, 6Radiology, Great Ormond Street Hospital, London, United Kingdom, 7Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany

Synopsis

Keywords: Spectroscopy, High-Field MRI, Paralel Transmit and B1 shimmingWe demonstrated that applying a fast implementation of an RF phase shimming method enabled the acquisition of localized MR spectra in different regions of the human brain including B1 challenging areas, such as the hippocampus and prefrontal cortex, using a commercially available pTx coil on a clinical platform at 7T. RF efficiency was increased by ~100% cerebellum and PFC while ~50-75% for pons and hippocampus. The most favorable flip angle distributions were obtained for the cerebellum and the prefrontal cortex. Fast B1 shimming with advanced MRS methodology enables high-quality single voxel spectra at 7T using a commercially available setup.

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