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Abstract #0495

Single-shot SLOW-editing for Downfield α-Glucose MRSI at 7T Utilizing SNR-Enhancing Glucose Mutarotation Effect

Guodong Weng1,2, Piotr Radojewski1,2, and Johannes Slotboom1,2
1Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland, 2Translational Imaging Center, sitem-insel, Bern, Switzerland

Synopsis

Keywords: Pulse Sequence Design, Spectroscopy, Spectral EditingChanges in brain glucose occur in many neurological disorders as well as during aging. Most studies on the uptake of glucose in the brain use positron emission tomography, which requires injection of a radioactive tracer. Our study shows that ultra-high-field 1H-MRS single-shot SLOW-editing can be used to measure α-D-glucose at 5.22 ppm in vivo, and thus that α-D-glucose might have the potential to be used as a an economic radiation free tracer in the human brain.

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